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Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial.
Plain-language guide to PMID 32272914 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 32272914
- Journal
- BMC pregnancy and childbirth
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- de Araújo CAL et al. (6 authors)
- DOI
- 10.1186/s12884-020-02877-0
- Registered trial
- NCT02032186
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Preeclampsia is the major cause of maternal morbidity and mortality in developing countries.
However there are doubts if magnesium supplementation during pregnancy can previne preeclampsia especially in population with high nutritional risk.
Who Took Part
By PubMed's age tags, the people studied were young adults and adults, women only.
This randomized, double-blind, placebo-controlled trial investigated the effect of oral magnesium citrate supplementation for preeclampsia in low-income Brazilian pregnant women, i.e. annual per capita income of US$ 1025 or less.
Participants were admitted to the study with gestational age between 12 and 20 weeks.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Magnesium serum level was measured pre-randomization and participants with hypermagnesemia were excluded.
What Was Measured
Topics PubMed links to this paper include Brazil, Dietary Supplements, Gestational Age, Magnesium Deficiency, Magnesium Sulfate, Poverty and Pre-Eclampsia.
Author keywords: Oral magnesium, Preeclampsia and Pregnancy.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (BMC pregnancy and childbirth), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.