Effects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy.

This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy.

Why It Was Studied

Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.

This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Data on health, safety, circulating 25(OH)D, and 9 immune-mediators were collected at each trimester.

Associations between immune-mediators and 25(OH)D at baseline and at second and third trimesters were examined.

What Was Measured

This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.

The subject headings attached to it are Cholecalciferol, Cytokines, Dietary Supplements, Ethnicity, Immune Tolerance, Intercellular Signaling Peptides and Proteins and Pregnancy Trimesters.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Pediatric research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.