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BRAzil magnesium (BRAMAG) trial: a double-masked randomized clinical trial of oral magnesium supplementation in pregnancy.
Plain-language guide to PMID 32316938 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 32316938
- Journal
- BMC pregnancy and childbirth
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- de Araújo CAL et al. (4 authors)
- DOI
- 10.1186/s12884-020-02935-7
- Registered trial
- NCT02032186
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
ClinicalTrials.gov NCT02032186, registered January 9, 2014.
Who Took Part
The age groups tagged for this paper are teenagers, young adults, adults and middle-aged adults, women only.
Eligible women were those with a singleton pregnancy and ≥ 1 risk factor, such as prior preterm birth or preeclampsia, or current chronic hypertension or pre-pregnancy diabetes mellitus, age > 35 years or elevated body mass index.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and multicenter study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
More than one site took part, so the participants came from several places.
This trial was completed in three centers in northeastern Brazil.
What Was Measured
The subject headings attached to it are Abruptio Placentae, Brazil, Citric Acid, Dietary Supplements, Gestational Age, Hypertension, Pregnancy-Induced and Infant, Small for Gestational Age.
The authors tagged it with the keywords Magnesium, Newborn, Preeclampsia, Preterm birth and Randomized clinical trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (BMC pregnancy and childbirth), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.