Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn's Disease Populations.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

Both trials were double blinded, randomized, placebo-controlled with cross-over.

Participants were randomly allocated to groups A (placebo then supplement) or B (supplement then placebo).

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Fatty acid (N-3 PUFAs) and vitamin D serum levels, plasma C-reactive protein (CRP), and stool calprotectin were measured before and after each treatment period.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

In the crossover set-up each of the participants took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Biological Availability, C-Reactive Protein, Crohn Disease, Dietary Supplements, Docosahexaenoic Acids, Eicosapentaenoic Acid and Fatty Acids.

The authors tagged it with the keywords 25-hydroxyvitamin D (25(OH)D), C-reactive protein (CRP), calprotectin, omega-3 and vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

The publication is from 2020 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.