← Human Trials & Peer-Reviewed Studies
A Pre-Workout Supplement of Ketone Salts, Caffeine, and Amino Acids Improves High-Intensity Exercise Performance in Keto-Naïve and Keto-Adapted Individuals.
Plain-language guide to PMID 32330107 (2020): crossover randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 32330107
- Journal
- Journal of the American College of Nutrition
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Kackley ML et al. (14 authors)
- DOI
- 10.1080/07315724.2020.1752846
What This Study Did, in Plain Language
What Was Tested
Researchers studied Copper (Supplement) in this randomized controlled trial publication.
Background: Acute ingestion of ketone supplements alters metabolism and potentially exercise performance.
No studies to date have evaluated the impact of co-ingestion of ketone salts with caffeine and amino acids on high intensity exercise performance, and no data exists in Keto-Adapted individuals.Methods: the researchers tested the performance and metabolic effects of a pre-workout supplement containing beta-hydroxybutyrate (BHB) salts, caffeine, and amino acids (KCA) in recreationally-active adults habitually consuming a mixed diet (Keto-Naïve; n = 12) or a ketogenic diet (Keto-Adapted; n = 12).
Who Took Part
PubMed indexes the participants as teenagers, young adults, adults and middle-aged adults, both men and women.
How the Study Was Run
The design is described as randomized and crossover.
Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.
In the crossover set-up each of the participants took both Copper (Supplement) and the comparison in turn, acting as their own control.
What Was Measured
No studies to date have evaluated the impact of co-ingestion of ketone salts with caffeine and amino acids on high intensity exercise performance, and no data exists in Keto-Adapted individuals.Methods: the researchers tested the performance and metabolic effects of a pre-workout supplement containing beta-hydroxybutyrate (BHB) salts, caffeine, and amino acids (KCA) in recreationally-active adults habitually consuming a mixed diet (Keto-Naïve; n = 12) or a ketogenic diet (Keto-Adapted; n = 12).
PubMed files the paper under topics including 3-Hydroxybutyric Acid, Adaptation, Physiological, Amino Acids, Bicycling, Caffeine, Diet, Ketogenic and Dietary Supplements.
Author keywords: Beta-hydroxybutyrate, exercise, ketones, metabolism and performance.
What This Means in Plain Language
The paper is a randomized and crossover study of Copper (Supplement).
The publication is from 2020 (Journal of the American College of Nutrition), a journal based in United States.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.