ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure

What Was Tested

The paper reports a study of ACTH (Corticotropin) and Cosyntropin, published as a randomized controlled trial.

Hypoglycemia attenuates cardiovascular homeostatic autonomic control.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

Participants included healthy men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received ACTH (Corticotropin).

Some participants received a placebo instead of ACTH (Corticotropin), giving a reference point.

Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.

A double-blind, placebo-controlled, random-order, cross-over study was conducted.

This study took place in a clinical research center.

What Was Measured

Topics PubMed links to this paper include Autonomic Nervous System Diseases, Baroreflex, Cosyntropin and Hypoglycemia.

The authors tagged it with the keywords ACTH, autonomic failure and cortisol.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and Cosyntropin.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the ACTH (Corticotropin) compound page and the Cosyntropin compound page, all human trials.