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Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial.
Plain-language guide to PMID 32353962 (2020): single-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 17 adults.
Key Facts
- PMID
- 32353962
- Journal
- Nutrients
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Zhan J et al. (8 authors)
- DOI
- 10.3390/nu12051245
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement), published as a randomized controlled trial.
The researchers conducted a pilot study to evaluate appropriate methods for assessing responses to the ingestion of oral magnesium supplements, including ionized magnesium in whole blood (iMg2+) concentration, serum total magnesium concentration, and total urinary magnesium content.
Who Took Part
The study group was 17 adults.
The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
In design terms this was a randomized, single-blind, placebo-controlled, crossover and pilot study.
The adults were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
In this single-blind Vitamin D, K2, Magnesium and Zinc study one party knew the assignments and the other did not.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.
What Was Measured
The subject headings attached to it are Biological Availability, Dietary Supplements, Eating, Healthy Volunteers, Magnesium Chloride, Nutritional Physiological Phenomena and Pilot Projects.
Author keywords: biomarkers, iMg and nutritional status.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 17 adults.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2020 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.
Our Notes on the Compounds
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.