← Human Trials & Peer-Reviewed Studies
The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: a double blind, randomized clinical trial.
Plain-language guide to PMID 32363556 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 186 women.
Key Facts
- PMID
- 32363556
- Journal
- Endocrine
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Rasheedy R et al. (4 authors)
- DOI
- 10.1007/s12020-020-02315-3
- Registered trial
- NCT03396380
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The aim of this study was to assess the effect of vitamin D supplementation on ovulation rate in overweight subfertile women with PCOS undergoing ovulation induction.
Who Took Part
According to the abstract, 186 women were involved.
PubMed tags the participants as women only.
The vitamin D or placebo supplementation started 1 month before induction cycles (total four cycles).
Cycles were monitored with ultrasound follicle tracking and mid-luteal serum progesterone measurement.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Groups ran in parallel: each of the women stayed in one arm throughout.
The primary outcome was the ovulation rate after three induction cycles.
What Was Measured
PubMed files the paper under topics including Clomiphene, Fertility Agents, Female, Infertility, Female, Overweight, Ovulation Induction, Polycystic Ovary Syndrome and Vitamin D.
The authors tagged it with the keywords Induction of ovulation, Polycystic ovaries, Reproductive endocrinology and Vitamin D and fertility in PCO.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 186 women.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (Endocrine), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.