Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The aim of this split-mouth, blinded randomized controlled trial was to evaluate the clinical and radiographic effects of locally delivered 1,25 dihydroxycholecalciferol (1,25 DHC) on the amount of canine distalization.

Descriptive statistics and paired t test were used to determine any differences.

Who Took Part

Fifteen patients between age groups of 15 years to 30 years willing to undergo orthodontic treatment in a dental college participated in the study.

A computer-generated randomization list was generated to divide the maxillary arch into experimental side and control side.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Patients were evaluated from beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3).

CT scans were taken at T0 and T3 to measure the changes in bone density.

The difference in amount of canine distalization and the changes in bone density were assessed on the experimental and control sides, respectively.

What Was Measured

PubMed files the paper under topics including Bone Density, Tomography, Spiral Computed, Tooth Movement Techniques, Vitamin D and Vitamins.

Author keywords: Canine distalization and Randomized controlled trial Vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (The journal of contemporary dental practice), a journal based in India.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.