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Randomized, assessor-blinded trial comparing highly purified human menotropin and recombinant follicle-stimulating hormone in high responders undergoing intracytoplasmic sperm injection
Plain-language guide to PMID 32416978 (2020): randomized and open-label clinical study of HMG (Human Menopausal Gonadotropin) in 620 women.
Key Facts
- PMID
- 32416978
- Journal
- Fertility and sterility
- Year
- 2020
- Study type
- Clinical Study
- Authors
- Witz CA et al. (7 authors)
- DOI
- 10.1016/j.fertnstert.2020.03.029
What This Study Did, in Plain Language
What Was Tested
Researchers studied HMG (Human Menopausal Gonadotropin) in this clinical study publication.
Who Took Part
According to the abstract, 620 women were involved.
By PubMed's age tags, the people studied were young adults and adults, both men and women.
A total of 620 women with serum antimüllerian hormone (AMH) ≥5 ng/mL.
How the Study Was Run
The design is described as randomized, open-label and parallel-group.
The women were allocated by chance, so the HMG (Human Menopausal Gonadotropin) group and the comparison group should start out alike.
Everyone knew when HMG (Human Menopausal Gonadotropin) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.
Groups ran in parallel: each of the women stayed in one arm throughout.
Controlled ovarian stimulation with HP-hMG or rFSH in a GnRH antagonist assisted reproductive technology (ART) cycle.
Fresh transfer of a single blastocyst was performed unless ovarian response was excessive, in which all embryos were cryopreserved.
What Was Measured
The subject headings attached to it are Abortion, Spontaneous, Anti-Mullerian Hormone, Biomarkers, Fertility, Fertility Agents, Female, Follicle Stimulating Hormone, Human and Infertility.
The authors tagged it with the keywords GnRH antagonist, Highly purified menotropin, Menopur, high responders and recombinant FSH.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of HMG (Human Menopausal Gonadotropin) in 620 women.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2020 (Fertility and sterility), a journal based in United States.
More context: the HMG (Human Menopausal Gonadotropin) compound page, all human trials.
Our Notes on the Compound
HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.