Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

What Was Tested

Researchers studied CGRP (Calcitonin Gene-Related Peptide) in the context of migraine in this randomized controlled trial publication.

Migraine is a complex disorder, involving peripheral and central brain structures, where mechanisms and site of attack initiation are an unresolved puzzle.

While abnormal pontine neuronal activation during migraine attacks has been reported, exact implication of this finding is unknown.

Who Took Part

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind and crossover study.

Because people in this CGRP (Calcitonin Gene-Related Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received CGRP (Calcitonin Gene-Related Peptide).

Each person switched between CGRP (Calcitonin Gene-Related Peptide) and the comparison at some point, usually with a gap in between.

What Was Measured

PubMed files the paper under topics including Arteries, Calcitonin Gene-Related Peptide, Cerebrovascular Circulation, Creatine, Energy Metabolism, Glutamic Acid and Magnetic Resonance Imaging.

The authors tagged it with the keywords Brainstem, headache and trigeminal.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of CGRP (Calcitonin Gene-Related Peptide) in people with migraine.

The publication is from 2021 (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism), a journal based in United States.

More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.