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Preoperative Vitamin D Supplementation in Patients With Vitamin D Deficiency Undergoing Total Thyroidectomy.
Plain-language guide to PMID 32466854 (2020): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 100 patients.
Key Facts
- PMID
- 32466854
- Journal
- The American journal of the medical sciences
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Ramouz A et al. (4 authors)
- DOI
- 10.1016/j.amjms.2020.04.036
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Considering the role of 25-hydroxyvitamin D (25(OH)D) in calcium hemostasis, this study aimed to evaluate the effect of preoperative vitamin D supplementation on hypocalcemia incidence in thyroidectomy patients.
Why It Was Studied
Transient hypocalcemia due to parathyroid gland or vessel manipulation is a common complication following thyroidectomy.
Who Took Part
The abstract describes 100 patients taking part.
PubMed indexes the participants as adults, both men and women.
In this randomized clinical trial, 100 patients scheduled for total thyroidectomy and suffering from preoperative moderate or severe vitamin D deficiency were enrolled.
Patients were randomly allocated to either study or control groups using the sealed envelope method.
How the Study Was Run
The researchers set it up as a randomized and placebo-controlled study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
The control group received placebo.
Total and ionized serum calcium levels were checked before surgery, the day after surgery, and 2 weeks postoperatively.
What Was Measured
The subject headings attached to it are Adenocarcinoma, Follicular, Calcium, Cholecalciferol, Goiter, Nodular, Hypocalcemia, Postoperative Complications and Preoperative Care.
The authors tagged it with the keywords Thyroidectomy and Vitamin D deficiency.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 100 patients.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (The American journal of the medical sciences), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.