Race-specific associations of 25-hydroxyvitamin D and parathyroid hormone with cardiometabolic biomarkers among US white and black postmenopausal women

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this observational study publication.

This study examined race (black/white)-specific independent and joint associations of 25(OH)D and PTH with cardiometabolic biomarkers including high-sensitivity C-reactive protein (hs-CRP), estimated glomerular filtration rate (eGFR), and homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-B).

Among 1500 white and 1300 black postmenopausal women without cardiovascular disease from the Women's Health Initiative Observational Study, a weighted linear regression analysis and a novel penalized spline-based semiparametric model with contour plots, accounting for possible nonlinear relations and interactions simultaneously, were used to investigate the race-specific independent and joint associations of 25(OH)D and PTH with each biomarker.

Why It Was Studied

Concentrations of 25-hydroxyvitamin D [25(OH)D] tend to be lower in African Americans than in non-Hispanic whites, but whether adding information on parathyroid hormone (PTH) can help explain the higher cardiometabolic risk among African Americans is unknown.

Who Took Part

The abstract describes 1300 women taking part.

PubMed indexes the participants as middle-aged adults and older adults, women only.

What Was Measured

Topics PubMed links to this paper include Black or African American, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Parathyroid Hormone, Postmenopause and Species Specificity.

Author keywords: 25-hydroxyvitamin D, cardiometabolic biomarkers, joint associations, postmenopausal women and racial differences.

What This Means in Plain Language

This is an observational study of Parathyroid Hormone (PTH 1-84) in 1300 women.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (The American journal of clinical nutrition), a journal based in United States.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.