← Human Trials & Peer-Reviewed Studies
The neuropeptide substance P regulates aldosterone secretion in human adrenals
Plain-language guide to PMID 32471973 (2020): randomized and double-blind clinical trial, phase iv study of Substance P.
Key Facts
- PMID
- 32471973
- Journal
- Nature communications
- Year
- 2020
- Study type
- Clinical Trial, Phase IV
- Authors
- Wils J et al. (15 authors)
- DOI
- 10.1038/s41467-020-16470-8
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Substance P, published as a clinical trial, phase iv.
The researchers also conducted a prospective proof-of-concept, double blind, placebo-controlled clinical trial aimed to investigate the impact of the NK1R antagonist aprepitant on aldosterone secretion in healthy male volunteers (EudraCT: 2008-003367-40, ClinicalTrial.gov: NCT00977223).
Why It Was Studied
Aldosterone, produced by the adrenals and under the control of plasma angiotensin and potassium levels, regulates hydromineral homeostasis and blood pressure.
Here the researchers report that the neuropeptide substance P (SP) released by intraadrenal nerve fibres, stimulates aldosterone secretion via binding to neurokinin type 1 receptors (NK1R) expressed by aldosterone-producing adrenocortical cells.
Who Took Part
The age groups tagged for this paper are teenagers, young adults and adults, men only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Substance P study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Substance P study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Substance P group a baseline to be compared against.
What Was Measured
Aldosterone, produced by the adrenals and under the control of plasma angiotensin and potassium levels, regulates hydromineral homeostasis and blood pressure.
The primary endpoint was plasma aldosterone levels during posture test.
Topics PubMed links to this paper include Adrenal Cortex, Adrenal Glands, Aldosterone, Aprepitant, Cells, Cultured, Hypoglycemia and Metoclopramide.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Substance P.
The publication is from 2020 (Nature communications), a journal based in England.
More context: the Substance P compound page, all human trials.
Our Notes on the Compound
Substance P: An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.