Differential Osteoprotegerin Kinetics after Stimulation with Desmopressin and Lipopolysaccharides In Vivo

What Was Tested

Researchers studied Vasopressin and Desmopressin in this randomized controlled trial publication.

The researchers aimed to assess these using two distinct in vivo models; one after stimulation with desmopressin (DDAVP) and another after stimulation with lipopolysaccharide (LPS).

Why It Was Studied

Within endothelial cells OPG is stored in Weibel-Palade bodies (WPBs).

Blood kinetics of OPG are essentially unknown.

Who Took Part

The abstract describes 31 volunteers taking part.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled, crossover and pilot study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the volunteers and researchers unaware of who received Vasopressin.

Some volunteers received a placebo instead of Vasopressin, giving a reference point.

Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.

What Was Measured

PubMed files the paper under topics including Austria, Biomarkers, Deamino Arginine Vasopressin, Endothelial Cells, Healthy Volunteers, Lipopolysaccharides and Osteoprotegerin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 31 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2020 (Thrombosis and haemostasis), a journal based in Germany.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.