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Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease.
Plain-language guide to PMID 32517192 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 52 individuals.
Key Facts
- PMID
- 32517192
- Journal
- Nutrients
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Alonso A et al. (6 authors)
- DOI
- 10.3390/nu12061697
- Registered trial
- NCT02837328
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Proteomic approaches can assist in identifying the underlying mechanisms.
The researchers evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels.
Who Took Part
According to the abstract, 52 individuals were involved.
PubMed indexes the participants as middle-aged adults, women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the individuals nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log2 scale.
What Was Measured
The researchers evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels.
Topics PubMed links to this paper include Biomarkers, Blood Proteins, Cardiovascular Diseases, Dietary Supplements, Interleukin-1 Receptor-Like 1 Protein, Magnesium and Magnesium Oxide.
Author keywords: proteomics and randomized trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 52 individuals.
The publication is from 2020 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.