Effects of perioperative magnesium sulfate infusion on intraoperative blood loss and postoperative analgesia in patients undergoing posterior lumbar spinal fusion surgery: A randomized controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Although several studies have been carried out to evaluate the anti-nociceptive effect of magnesium, there is still considerable uncertainty.

Who Took Part

PubMed indexes the participants as young adults, adults, middle-aged adults, older adults and people over 80, both men and women.

Eighty patients who underwent posterior spinal fusion were randomly divided into two groups (magnesium and saline).

Morphine consumption was evaluated at regular times after the surgery by patient controlled analgesia (PCA) device.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Changes in cell count, magnesium concentration and coagulation status were assessed one hour after operation at both group and compared to baseline.

At recovery room, their pain score was assessed according to 10 points visual analogue scale (VAS).

What Was Measured

Topics PubMed links to this paper include Analgesia, Patient-Controlled, Analgesics, Opioid, Bleeding Time, Blood Coagulation, Blood Loss, Surgical, Central Nervous System Sensitization and International Normalized Ratio.

The authors tagged it with the keywords Magnesium sulfate, Posterior spinal fusion and Postoperative analgesia.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Clinical neurology and neurosurgery), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.