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Effect of daily versus vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial.
Plain-language guide to PMID 32542307 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 32542307
- Journal
- The American journal of clinical nutrition
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Abderhalden LA et al. (13 authors)
- DOI
- 10.1093/ajcn/nqaa145
- Registered trial
- NCT00599807
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
Observational studies report higher blood pressure (BP) among individuals with lower 25-hydroxyvitamin D concentration.
Who Took Part
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
This randomized, double-blind, ancillary trial of the Zurich Multiple Endpoint Vitamin D Trial in Knee Osteoarthritis enrolled adults aged ≥60 y who underwent elective surgery due to severe knee osteoarthritis.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Outcomes included daytime and 24-h mean systolic BP.
BP variability and serum 25-hydroxyvitamin D concentration were examined in a post hoc and observational analysis.
What Was Measured
The subject headings attached to it are Blood Pressure, Hypertension, Vitamin D and Vitamins.
Author keywords: 25(OH)D, ARV, blood pressure variability, older adults and supplement.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (The American journal of clinical nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Vitamin D, K2, Magnesium and Zinc in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.