Effect of positive end-expiratory pressure ventilation on plasma nitric oxide, endothelin-1 and vascular celladhesion molecule-1 levels in patients undergoing uvulopalatopharyngoplasty

What Was Tested

This randomized controlled trial paper looks at Endothelin-1.

To evaluate the effect of the protective ventilation strategy on the function of vascular endothelial cells.

Why It Was Studied

During uvulopalatopharyngoplasty (UPPP), cardiovascular adverse events may occur which can be harmful to patients.

Who Took Part

Forty obstructive apnea syndrome (OSA) patients who underwent uvulopalatopharyngoplasty (UPPP) were enrolled.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Endothelin-1 and who got the comparison, which limits bias.

Blood from the radial artery was sampled for blood gas analysis at four time points: the fifth minute of inhaling pure oxygen (T0), after tracheal intubation (T1), at the end of the operation (T2), and 20 minutes after extubation (T3).

Three ml of arterial blood was retained, preserved at -20∘C after serum isolation, and plasma nitric oxide (NO), endothelin-1 (ET-1) and vascular celladhesion molecule-1 (VCAM-1) levels were determined by enzyme linked immunosorbent assay (ELISA).

What Was Measured

The subject headings attached to it are Endothelial Cells, Endothelin-1, Nitric Oxide, Positive-Pressure Respiration and Tidal Volume.

The authors tagged it with the keywords Positive end-expiratory pressure ventilation, general anesthesia, vascular adhesion factor and vascular relaxing factor.

What This Means in Plain Language

The paper is a randomized study of Endothelin-1.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Technology and health care : official journal of the European Society for Engineering and Medicine), a journal based in United States.

More context: the Endothelin-1 compound page, all human trials.