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Carnosine and histidine-containing dipeptides improve dyslipidemia: a systematic review and meta-analysis of randomized controlled trials.
Plain-language guide to PMID 32594145 (2020): meta-analysis of Carnosine.
Key Facts
- PMID
- 32594145
- Journal
- Nutrition reviews
- Year
- 2020
- Study type
- Meta-Analysis
- Authors
- Menon K et al. (6 authors)
- DOI
- 10.1093/nutrit/nuaa022
What This Paper Covers, in Plain Language
What It Covers
This meta-analysis looks at Carnosine.
Carnosine and other histidine-containing dipeptides (HCDs) have exerted positive effects on cardiovascular risk factors and diseases in animal and human studies.
The authors conducted a systematic review and meta-analysis examining the effects of HCDs on cardiovascular outcomes in line with the PRISMA guidelines.
The grading of recommendations assessment, development, and evaluation approach was used to assess the quality of evidence for each outcome.
Why It Was Studied
The Medline, Medline in process, Embase, Cumulative Index of Nursing and Allied Health, and All EBM databases were searched from inception until January 25, 2019, for randomized controlled trials (RCTs) examining the effects of HCDs on cardiovascular outcomes, compared with placebo or controls.
Basic characteristics of the study and populations, interventions, and study results were extracted.
How the Review Was Done
A total of 21 studies were included.
What Was Measured
The Medline, Medline in process, Embase, Cumulative Index of Nursing and Allied Health, and All EBM databases were searched from inception until January 25, 2019, for randomized controlled trials (RCTs) examining the effects of HCDs on cardiovascular outcomes, compared with placebo or controls.
Topics PubMed links to this paper include Cardiovascular Diseases, Carnosine, Dietary Supplements, Dipeptides, Dyslipidemias, Histidine and Randomized Controlled Trials as Topic.
The authors tagged it with the keywords histidine-containing dipeptides and lipids.
What This Means in Plain Language
This is a meta-analysis of Carnosine.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (Nutrition reviews), a journal based in United States.
More context: the Carnosine compound page, all human trials.
Our Notes on the Compound
Carnosine: A dipeptide of beta-alanine and histidine found in muscle and brain; studied as a supplement in human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.