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Combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status in adults: a double-blind placebo-controlled randomised crossover clinical trial.
Plain-language guide to PMID 32660675 (2021): double-blind randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 32660675
- Journal
- The British journal of nutrition
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Pekas EJ et al. (8 authors)
- DOI
- 10.1017/S0007114520002548
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Copper (Supplement), published as a randomized controlled trial.
The purpose of this study was to investigate the impacts of a combined anthocyanins and bromelain supplement (BE) on endothelial function, BP, TAC, oxygen utility capacity and fatigability in healthy adults.
Why It Was Studied
Healthy adults (n 18, age 24 (sd 4) years) received BE or placebo in a randomised crossover design.
Who Took Part
By PubMed's age tags, the people studied were teenagers and young adults, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and crossover study.
Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.
Each person switched between Copper (Supplement) and the comparison at some point, usually with a gap in between.
Brachial artery flow-mediated dilation (FMD), BP, TAC, resting heart rate, oxygen utility capacity and fatigability were measured pre- and post-BE and placebo intake.
What Was Measured
Topics PubMed links to this paper include Anthocyanins, Antioxidants, Blood Pressure, Brachial Artery, Bromelains, Dietary Supplements and Endothelium, Vascular.
The authors tagged it with the keywords Flavonoids, Oxidative stress and Total antioxidant capacity.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).
The publication is from 2021 (The British journal of nutrition), a journal based in England.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.