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[Effect of a Mediterranean-pattern diet on the metabolic response secondary to weight loss; role of the single nucleotide polymorphism (rs16147) of neuropeptide Y]
Plain-language guide to PMID 32686440 (2020): randomized controlled trial study of Neuropeptide Y in 363 subjects.
Key Facts
- PMID
- 32686440
- Journal
- Nutricion hospitalaria
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Primo Martín D et al. (9 authors)
- DOI
- 10.20960/nh.02941
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Neuropeptide Y, published as a randomized controlled trial.
The researchers propose to evaluate the role of the rs16147 genetic variant in the metabolic effects produced by a hypocaloric Mediterranean-pattern diet with high content of omega-9.
Why It Was Studied
Background and aims: intervention studies that evaluate the effect of rs16147 on metabolic response and weight change after dietary intervention are scarce.
At the baseline visit the patients were randomly assigned to one of two hypocaloric diets for 12 weeks (diet M, Mediterranean pattern; diet C, standard hypocaloric).
Who Took Part
According to the abstract, 363 subjects were involved.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
Material and methods: a sample of 363 obese subjects was recruited.
How the Study Was Run
The researchers set it up as a randomized study.
The subjects were allocated by chance, so the Neuropeptide Y group and the comparison group should start out alike.
What Was Measured
Background and aims: intervention studies that evaluate the effect of rs16147 on metabolic response and weight change after dietary intervention are scarce.
All patients, at baseline and at 12 weeks, had biochemical and anthropometric variables measured, and genotyping performed for the rs16147 variant.
The subject headings attached to it are Diet, Mediterranean, Neuropeptide Y, Obesity, Polymorphism, Single Nucleotide and Weight Loss.
The authors tagged it with the keywords rs16147. Gen NPY. SNP. Adipocitoquinas. Dieta mediterránea..
What This Means in Plain Language
The paper is a randomized study of Neuropeptide Y in 363 subjects.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2020 (Nutricion hospitalaria), a journal based in Spain.
More context: the Neuropeptide Y compound page, all human trials.
Our Notes on the Compound
Neuropeptide Y: A 36-amino-acid brain and nerve peptide involved in appetite, stress and blood-vessel tone; studied as an intranasal spray.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.