The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

The study group was 62 participants.

The age groups tagged for this paper are young adults and adults, women only.

Participants took their allocated supplements over a 24-hr period with serum 25(OH)D retested 4 weeks later.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Liquid chromatography-tandem mass spectrometry method was applied to dried blood spot samples by an independent laboratory.

What Was Measured

The subject headings attached to it are Administration, Topical, Dietary Supplements, Healthy Volunteers, Skin, Vitamin D, Vitamins and White People.

Author keywords: Human, Oral liquid, Pill and Skin penetrator enhancer.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 62 participants.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.