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Glycemic Response to a Renal-Specific Oral Nutritional Supplement in Patients With Diabetes Undergoing Hemodialysis: A Randomized Crossover Trial.
Plain-language guide to PMID 32713006 (2021): single-blind randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 32713006
- Journal
- JPEN. Journal of parenteral and enteral nutrition
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Patel VN et al. (6 authors)
- DOI
- 10.1002/jpen.1970
What This Study Did, in Plain Language
What Was Tested
Researchers studied Copper (Supplement) in this randomized controlled trial publication.
The researchers aimed to evaluate the postprandial glucose response to oral nutritional supplement drinks (ONSs) in patients with diabetes undergoing hemodialysis treatment.
Why It Was Studied
Diabetes and malnutrition are common in patients with kidney failure.
Who Took Part
A randomized, single-blind crossover study was conducted in patients with diabetes, and requiring chronic hemodialysis.
Patients consumed either a renal-specific ONS, macronutrient-matched ONS, or standard ONS on 3 separate study days, during dialysis, following an overnight fast.
How the Study Was Run
In design terms this was a randomized, single-blind and crossover study.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
Only one side, usually the participants, was kept unaware of whether Copper (Supplement) was given.
In the crossover set-up each of the participants took both Copper (Supplement) and the comparison in turn, acting as their own control.
Blood was collected before and 15, 30, 45, 60, 90, 120, and 180 minutes post ingestion.
Mean net incremental area under the curve (iAUC) and peak incremental blood glucose concentration were compared across conditions, using analyses of variance.
What Was Measured
The subject headings attached to it are Blood Glucose, Diabetes Mellitus, Postprandial Period and Renal Dialysis.
Author keywords: adult, enteral nutrition, outcomes research/quality and renal disease.
What This Means in Plain Language
The paper is a randomized, single-blind and crossover study of Copper (Supplement).
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2021 (JPEN. Journal of parenteral and enteral nutrition), a journal based in United States.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.