← Human Trials & Peer-Reviewed Studies
Automatic Imitation in Comorbid PTSD & Alcohol Use Disorder and Controls: an RCT of Intranasal Oxytocin
Plain-language guide to PMID 32745891 (2020): double-blind randomized controlled trial study of Oxytocin in 49 participants.
Key Facts
- PMID
- 32745891
- Journal
- Psychoneuroendocrinology
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Morrison TE et al. (8 authors)
- DOI
- 10.1016/j.psyneuen.2020.104787
What This Study Did, in Plain Language
What Was Tested
Researchers studied Oxytocin in this randomized controlled trial publication.
Mimicking movements of others makes both the imitating and imitated partners feel closer.
This study attempts to replicate effects on HC and examine effects on people with comorbid posttraumatic stress disorder and alcohol use disorder (PTSD-AUD).
Who Took Part
According to the abstract, 49 participants were involved.
By PubMed's age tags, the people studied were adults and middle-aged adults, men only.
After exclusions, the final analyzed data set included 49 participants with PTSD-AUD and 38 HC.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Oxytocin.
A placebo (an inactive look-alike) gave the Oxytocin group a baseline to be compared against.
Each person switched between Oxytocin and the comparison at some point, usually with a gap in between.
At 135 min post-administration, each performed the imitation-inhibition task, which quantifies automatic imitation as the congruency effect (CE).
What Was Measured
The subject headings attached to it are Alcoholism, Comorbidity, Imitative Behavior, Inhibition, Psychological, Oxytocin and Stress Disorders, Post-Traumatic.
Author keywords: Intranasal administration, Post-traumatic stress disorders and Psychological inhibition.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Oxytocin in 49 participants.
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2020 (Psychoneuroendocrinology), a journal based in England.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.