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Effect of GnRH agonist before IVF on outcomes in infertile endometriosis patients: a randomized controlled trial
Plain-language guide to PMID 32782170 (2020): single-blind randomized controlled trial study of Triptorelin in 200 women, endometriosis.
Key Facts
- PMID
- 32782170
- Journal
- Reproductive biomedicine online
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Rodríguez-Tárrega E et al. (8 authors)
- DOI
- 10.1016/j.rbmo.2020.06.020
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Triptorelin in the context of endometriosis.
Who Took Part
The study group was 200 women.
The age groups tagged for this paper are adults, women only.
Single-blind, placebo-controlled clinical trial of 200 infertile women with endometriosis assigned to use GnRHa (study group) or placebo (control group) for 3 months before IVF.
In a subgroup of 40 patients, follicular fluid levels of oestradiol, testosterone and androstendione were measured.
How the Study Was Run
The researchers set it up as a randomized, single-blind and placebo-controlled study.
The women were allocated by chance, so the Triptorelin group and the comparison group should start out alike.
Only one side, usually the women, was kept unaware of whether Triptorelin was given.
A placebo (an inactive look-alike) gave the Triptorelin group a baseline to be compared against.
The timeline in the abstract includes 3 months.
Clinical, embryological outcomes and stimulation parameters were analysed.
Clinical pregnancy rate was the primary endpoint.
Gene expression profile of CYP19A1 was analysed in cumulus and mural granulosa cells.
What Was Measured
PubMed files the paper under topics including Androstenedione, Aromatase, Endometriosis, Estradiol, Fertilization in Vitro, Follicular Fluid and Gonadotropin-Releasing Hormone.
The authors tagged it with the keywords CYP19A1 gene, GnRH agonist and IVF.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of Triptorelin in 200 women in people with endometriosis over 3 months.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (Reproductive biomedicine online), a journal based in Netherlands.
More context: the Triptorelin compound page, Endometriosis research.
Our Notes on the Compound
Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.