Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Their aim was to examine the combined effect of early and late prenatal VD status in during pregnancies in women with and without asthma on childhood asthma or recurrent wheeze development.

Why It Was Studied

Childhood asthma developmental programming is complex.

Maternal asthma is a strong risk factor for childhood asthma, whereas vitamin D (VD) has emerged as a modifiable prenatal exposure.

Who Took Part

PubMed indexes the participants as young children, children, young adults and adults, both men and women.

Their main exposure was an ordered variable representing early and late prenatal VD sufficiency (25(OH)D level ≥ 30 ng/mL) status during pregnancy in women with and without asthma.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The primary outcome was offspring with asthma or recurrent wheeze by age 3 years.

The researchers also examined the effect of prenatal VD level on early life asthma or recurrent wheeze progression to active asthma at age 6 years.

What Was Measured

The subject headings attached to it are Asthma, Cohort Studies, Dietary Supplements, Maternal Exposure, Placebo Effect, Pregnancy Trimesters and Prenatal Exposure Delayed Effects.

Author keywords: childhood, maternal asthma, recurrent wheeze and vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2021 (The Journal of allergy and clinical immunology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.