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The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial.
Plain-language guide to PMID 32823974 (2020): double-blind randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 32823974
- Journal
- Nutrients
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Fantacone ML et al. (10 authors)
- DOI
- 10.3390/nu12082447
- Registered trial
- NCT02876315
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Copper (Supplement), published as a randomized controlled trial.
Prior to and after treatment, the researchers measured (1) their blood mineral and vitamin status (i.e., vitamin C, zinc and vitamin D); (2) immune function (i.e., whole blood bacterial killing activity, neutrophil phagocytic activity, and reactive oxygen species production); (3) immune status (salivary IgA and plasma cytokine/chemokine levels); and (4) self-reported health status.
Who Took Part
The age groups tagged for this paper are older adults and people over 80, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.
What Was Measured
Prior to and after treatment, the researchers measured (1) their blood mineral and vitamin status (i.e., vitamin C, zinc and vitamin D); (2) immune function (i.e., whole blood bacterial killing activity, neutrophil phagocytic activity, and reactive oxygen species production); (3) immune status (salivary IgA and plasma cytokine/chemokine levels); and (4) self-reported health status.
PubMed files the paper under topics including Age Factors, Aging, Cytokines, Dietary Supplements, Eating, Elder Nutritional Physiological Phenomena and Immunoglobulin A.
The authors tagged it with the keywords illness, immune, multivitamin, placebo, randomized clinical trial and vitamin C.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).
The publication is from 2020 (Nutrients), a journal based in Switzerland.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.