Vitamin D Supplementation Modulates ICOS+ and ICOS- Regulatory T Cell in Siblings of Children With Type 1 Diabetes.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this clinical trial publication.

Vitamin D plays an immunoregulatory activity.

The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/inducible costimulatory-positive (ICOS+), which seems to have a protective role in autoimmunity, in children with type 1 diabetes mellitus (T1D) and their healthy siblings (S).

The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

Who Took Part

The age groups tagged for this paper are children, both men and women.

22 T1D and 33 S were enrolled.

According to human leukocyte antigen (HLA) haplotypes, subjects were classified as "at risk" (HLA+), "protective haplotypes" (HLA-; "nested controls"), and "undetermined" (HLAUND).

How the Study Was Run

Glucose, hemoglobin A1c, 25 OH vitamin D (25[OH]D), T helper type 17 (Th17; CD4+CCR6+), regulatory T cells (Treg; CD4+CD25+Foxp3+), and Treg/ICOS+ cells were evaluated.

What Was Measured

Topics PubMed links to this paper include Diabetes Mellitus, Type 1, Dietary Supplements, Inducible T-Cell Co-Stimulator Protein, Italy, Lymphocyte Count, Siblings and T-Lymphocytes, Regulatory.

The authors tagged it with the keywords Th 17, Treg, Type 1 diabetes, immunomodulation and vitamin D.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.