Association between maternal or cord blood concentrations of 25-hydroxycholecalciferol or vitamin D supplementation during pregnancy and the cytokines profile in the umbilical cord blood: Systematic literature review.

What It Covers

This systematic review looks at Vitamin D, K2, Magnesium and Zinc.

To assess, through a systematic literature review, the relationship between maternal or cord blood concentrations of 25-hydroxycholecalciferol (25-OH-D) or vitamin D supplementation during pregnancy and the cytokines profile in the umbilical cord.

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

The following databases were searched: PUBMED, CENTRAL, Web of Science, LILACS, and gray literature, up to July 2020.

The search strategy included terms related to the exposure (25-OH-D) and the primary outcome (cytokines).

Observational studies and randomized clinical trials were included, measuring cytokines in the umbilical cord blood, or in ex vivo bioassays, and blood concentrations of 25-OH-D, either throughout pregnancy or in the umbilical cord blood.

Studies with twin pregnancies, with placental or autoimmune diseases, were excluded.

The protocol is registered in PROSPERO (number CRD42019136643).

What Was Measured

The subject headings attached to it are Calcifediol, Cytokines, Dietary Supplements, Fetal Blood, Observational Studies as Topic, Randomized Controlled Trials as Topic and Vitamin D.

Author keywords: Placental immunology, T lymphocytes and Umbilical cord.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (The Journal of steroid biochemistry and molecular biology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.