Bone mineral density and vitamin D in paediatric intestinal failure patients receiving home parenteral nutrition.

Plain-language guide to PMID 32859323 (2020): observational study of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 32859323
Journal: Clinical nutrition ESPEN
Year: 2020
Study type: Observational Study
Authors: Kvammen JA et al. (10 authors)
DOI: 10.1016/j.clnesp.2020.06.006

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

Patients with intestinal failure (IF) are dependent on long-term home parenteral nutrition (HPN) to ensure growth and development.

The primary aim of the present study was to assess bone mineral density (BMD) and vitamin D status in paediatric IF patients on HPN and a group of healthy children aged 2-18 years.

Secondary aims were to assess growth, body composition, nutrient provision and physical activity.

Why It Was Studied

Clinical Trials AEV2017/1. 2016/391/REK sør-øst B REVISION NUMBER: CLNESP-D-20-00022.

Who Took Part

The age groups tagged for this paper are children.

An observational cross-sectional study was performed at Oslo University Hospital and at the Department of Nutrition, University of Oslo, from January to September 2017.

Weight and height were measured for growth assessment.

How the Study Was Run

BMD z-score (BMDz) was calculated for total body and lumbar spine L2-L4 based on the integrated reference population in the software.

Nutrient provision was assessed by a 4-day food record.

Blood samples were analysed for 25-hydroxy-vitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D).

Physical activity was reported by a questionnaire.

What Was Measured

Topics PubMed links to this paper include Absorptiometry, Photon, Bone Density, Cross-Sectional Studies, Parenteral Nutrition, Home and Vitamin D.

The authors tagged it with the keywords Bone mineral density, Children, Growth, Home parenteral nutrition and Intestinal failure.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 14 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.