Vitamin D Deficiency Is Associated with Severity of Dry Eye Symptoms and Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in this meta-analysis publication.

The researchers aimed to examine the correlations between vitamin D deficiency, severity of dry eye symptoms and primary Sjögren's syndrome (pSS) by performing a systematic review and meta-analysis.

Why It Was Studied

Online databases (PubMed, Cochrane Library, and Embase) were searched to identify controlled studies comparing (1) severity of dry eye symptoms between participants with and without vitamin D deficiency; and (2) serum vitamin D levels between patients with and without pSS.

Overall, individuals with vitamin D deficiency had shorter tear breakup time (TBUT), lower Schirmer's test scores and higher ocular surface disease index (OSDI) score than those without vitamin D deficiency.

Who the Included Studies Covered

PubMed tags the participants as both men and women.

What Was Measured

Online databases (PubMed, Cochrane Library, and Embase) were searched to identify controlled studies comparing (1) severity of dry eye symptoms between participants with and without vitamin D deficiency; and (2) serum vitamin D levels between patients with and without pSS.

Overall, individuals with vitamin D deficiency had shorter tear breakup time (TBUT), lower Schirmer's test scores and higher ocular surface disease index (OSDI) score than those without vitamin D deficiency.

Topics PubMed links to this paper include Dry Eye Syndromes, Sjogren's Syndrome, Tears, Vitamin D and Vitamin D Deficiency.

The authors tagged it with the keywords Schirmer’s test, Th1 cells, Th17 cells, interleukin 6, ocular surface disease index and tear breakup time.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2020 (Journal of nutritional science and vitaminology), a journal based in Japan.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.