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Treatment With Angiotensin II Is Associated With Rapid Blood Pressure Response and Vasopressor Sparing in Patients With Vasoplegia After Cardiac Surgery: A Post-Hoc Analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study
Plain-language guide to PMID 32868152 (2021): placebo-controlled randomized controlled trial study of Angiotensin II, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 32868152
- Journal
- Journal of cardiothoracic and vascular anesthesia
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Klijian A et al. (10 authors)
- DOI
- 10.1053/j.jvca.2020.08.001
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Angiotensin II in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
The present study investigated outcomes in patients with vasoplegia after cardiac surgery treated with angiotensin II plus standard-of-care vasopressors.
Who Took Part
Post-hoc analysis of the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) study.
Sixteen patients with vasoplegia after cardiac surgery with cardiopulmonary bypass were enrolled.
How the Study Was Run
In design terms this was a randomized, placebo-controlled and multicenter study.
The participants were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
The comparison arm used a placebo, so changes seen with Angiotensin II could be set against what happens without it.
Running at several centres spread the Angiotensin II study over different clinics and patient groups.
Angiotensin II plus standard-of-care vasopressors (n = 9) compared with placebo plus standard-of-care vasopressors (n = 7).
What Was Measured
Topics PubMed links to this paper include Angiotensin II, Blood Pressure, Cardiac Surgical Procedures, Cardiopulmonary Bypass, Vasoconstrictor Agents and Vasoplegia.
The authors tagged it with the keywords cardiac surgery and shock.
What This Means in Plain Language
The paper is a randomized, placebo-controlled and multicenter study of Angiotensin II in people with low blood pressure and orthostatic hypotension.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2021 (Journal of cardiothoracic and vascular anesthesia), a journal based in United States.
More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.