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Modulation of TRPV-1 by prostaglandin-E(2) and bradykinin changes cough sensitivity and autonomic regulation of cardiac rhythm in healthy subjects
Plain-language guide to PMID 32938990 (2020): double-blind randomized controlled trial study of Bradykinin.
Key Facts
- PMID
- 32938990
- Journal
- Scientific reports
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Liviero F et al. (9 authors)
- DOI
- 10.1038/s41598-020-72062-y
What This Study Did, in Plain Language
What Was Tested
Researchers studied Bradykinin in this randomized controlled trial publication.
A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution.
The researchers tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
How the Study Was Run
In design terms this was a randomized and double-blind study.
Because people in this Bradykinin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Bradykinin.
Subsequently, the response to CPS was assessed by cough challenge and the sympathetic activity by HRV, expressed by low (nLF) and high (nHF) normalized frequency components, as well as nLF/nHF ratio.
What Was Measured
The researchers tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).
Moreover, the researchers assessed the molecular mechanism of TRPV-1 modulation in vitro.
Topics PubMed links to this paper include Administration, Inhalation, Autonomic Nervous System, Bradykinin, Capsaicin, Cough, Dinoprostone and HeLa Cells.
What This Means in Plain Language
The paper is a randomized and double-blind study of Bradykinin.
The publication is from 2020 (Scientific reports), a journal based in England.
More context: the Bradykinin compound page, all human trials.
Our Notes on the Compound
Bradykinin: A 9-amino-acid peptide that widens blood vessels and causes swelling; given in research studies of blood flow.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.