Antinociceptive effects of magnesium sulfate for monitored anesthesia care during hysteroscopy: a randomized controlled study.

Plain-language guide to PMID 32957926 (2020): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 32957926
Journal: BMC anesthesiology
Year: 2020
Study type: Randomized Controlled Trial
Authors: Gao PF et al. (7 authors)
DOI: 10.1186/s12871-020-01158-9

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

ChiCTR1900024596. date of registration: July 18th 2019.

Who Took Part

The age groups tagged for this paper are adults, women only.

Seventy patients scheduled for hysteroscopy were randomly divided into 2 groups.

Patients in the control group (Group C) received an equal volume of isotonic saline as placebo.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

All patients were anesthetized under a BIS guided monitored anesthesia care with propofol and fentanyl.

Intraoperative hemodynamic variables were recorded and postoperative pain scores were assessed with verbal numerical rating scale (VNRS) 1 min, 15 min, 30 min, 1 h, and 4 h after recovery of consciousness.

The primary outcome of their study was total amount of intraoperative and postoperative analgesics administered.

What Was Measured

Topics PubMed links to this paper include Analgesics, Analgesics, Opioid, Anesthesia, Anesthetics, Fentanyl, Hysteroscopy and Magnesium Sulfate.

The authors tagged it with the keywords Magnesium sulphate, Monitored anesthesia care and Pain.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (BMC anesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.