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Effect of Vitamin D Supplementation on Disposition Index in Non-Diabetic Indians with Obesity: A Double-Blind Randomized Placebo-Controlled Trial.
Plain-language guide to PMID 32996330 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 101 subjects.
Key Facts
- PMID
- 32996330
- Journal
- Journal of dietary supplements
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Pragya PhD P et al. (4 authors)
- DOI
- 10.1080/19390211.2020.1827116
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
This double-blind randomized placebo-controlled trial was designed to investigate the effect of vitamin D3 supplementation on the disposition index in non-diabetic Indian subjects with obesity.
Why It Was Studied
There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis.
The primary outcome was a change in disposition index (DI) and secondary outcome measures were change in the homeostatic model assessment of insulin resistance and change in body composition.
Who Took Part
The study group was 101 subjects.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the subjects nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
The primary outcome was a change in disposition index (DI) and secondary outcome measures were change in the homeostatic model assessment of insulin resistance and change in body composition.
The subject headings attached to it are Cholecalciferol, Dietary Supplements, Obesity, Vitamin D and Vitamins.
The authors tagged it with the keywords 25(OH) D, disposition index, insulin resistance, insulin sensitivity and vitamin D supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 101 subjects.
The publication is from 2021 (Journal of dietary supplements), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.