Mechanism for the Increase in Human Growth Hormone with Administration of a Novel Test Supplement and Results Indicating Improved Physical Fitness and Sleep Efficiency.

Plain-language guide to PMID 33030391 (2021): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Copper (Supplement) in 16 participants.

Key Facts

PMID: 33030391
Journal: Journal of medicinal food
Year: 2021
Study type: Randomized Controlled Trial
Authors: Heaton AL et al. (5 authors)
DOI: 10.1089/jmf.2020.0109
Registered trial: NCT02987868

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Copper (Supplement).

Who Took Part

The abstract describes 16 participants taking part.

The age groups tagged for this paper are adults.

In Study 1, serum triiodothyronine (T3) was measured in samples from a prior placebo-controlled, double-blind study in which 16 healthy participants received both placebo and the test supplement in a crossover design; treatment order was randomized, and treatments were separated by a 1-week washout.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled, crossover and pilot study.

The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Some participants received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.

Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Human Growth Hormone, Physical Fitness and Sleep.

The authors tagged it with the keywords growth hormone secretagogue, insulin-like growth factor-1 and somatostatin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Copper (Supplement) in 16 participants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2021 (Journal of medicinal food), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the Copper (Supplement) compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.