Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19).

Plain-language guide to PMID 33039952 (2020): observational study of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12) in 2020, patients.

Key Facts

PMID: 33039952
Journal: Nutrition (Burbank, Los Angeles County, Calif.)
Year: 2020
Study type: Observational Study
Authors: Tan CW et al. (14 authors)
DOI: 10.1016/j.nut.2020.111017

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12) in this observational study publication.

The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not.

The researchers hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.

Who Took Part

The study group was 2020, patients.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital.

Before April 6, 2020, no patients received the (DMB) combination.

How the Study Was Run

Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.

What Was Measured

The subject headings attached to it are COVID-19, Cohort Studies, Critical Care, Disease Progression, Hospitalization, Magnesium and Micronutrients.

The authors tagged it with the keywords Vitamin B(12)COVID-19 and Vitamin D.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12) in 2020, patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Nutrition (Burbank, Los Angeles County, Calif.)), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Cyanocobalamin (Vitamin B12) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.