Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial.

Plain-language guide to PMID 33054794 (2020): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 33054794
Journal: BMC pregnancy and childbirth
Year: 2020
Study type: Randomized Controlled Trial
Authors: Motamed S et al. (6 authors)
DOI: 10.1186/s12884-020-03311-1
Registered trial: NCT03308487

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

To determine the effects of vitamin D supplementation on metabolic markers 1-factor repeated-measures analysis of variance (ANOVA) was used.

Why It Was Studied

This trial is registered at clinicaltrials.gov ( NCT03308487 ).

Registered 12 October 2017 'retrospectively registered'.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, women only.

Biochemical assessments of mothers including serum concentrations of 25(OH)D, calcium, phosphate, iPTH, fasting serum sugar (FBS), insulin, triglyceride, total cholesterol, LDL-C, HDL-C, malondialdehyde (MDA) and total antioxidant capacity (TAC) were done at the beginning and 34 weeks of gestation.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Cord blood serum concentrations of 25(OH)D, iPTH, MDA and TAC were assessed at delivery as well.

Between groups comparisons was done by using Independent-samples Student's t-test or Mann-Whitney test.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Blood Glucose, Fetal Blood, Lipids, Oxidative Stress, Pregnancy Complications and Vitamin D.

The authors tagged it with the keywords Glycemic status; lipid profile and Vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (BMC pregnancy and childbirth), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.