Evaluation of the effect of vitamin D3 supplementation on quantitative and qualitative parameters of spermograms and hormones in infertile men: A Randomized controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Their study aimed to evaluate the effect of oral vitamin D3 supplementation on spermogram quantitative and qualitative parameters in infertile men.

Why It Was Studied

25-Hydroxy Vitamin D3 is known to have an effect on reproductive system in both genders and may change the semen parameters in men.

Who Took Part

The study group was 62 men.

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, men only.

This study was a triple-blind randomized controlled trial involving 62 infertile men with impaired spermatogonial tests.

They were randomly divided into placebo and D3-supplemented groups.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Spermograms and tests for LH (Luteinizing Hormone), FSH (Follicle Stimulating Hormone), TT (Total Testosterone), FT (Free Testosterone), SHBG (Sex Hormone Bonding Globulin), FAI (Free Androgen Index) and vitamin D3 levels were performed before and after the intervention.

What Was Measured

The subject headings attached to it are Biomarkers, Cholecalciferol, Dietary Supplements, Gonadal Steroid Hormones, Infertility, Male, Semen and Semen Analysis.

The authors tagged it with the keywords Male infertility, Sex hormones and Vitamin D(3).

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 62 men.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Complementary therapies in medicine), a journal based in Scotland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.