Metabolomic basis for response to high dose vitamin D in critical illness.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

It is unclear if intervention can mitigate the dramatic alterations of metabolic homeostasis present in critical illness.

Who Took Part

The abstract describes 428 subjects taking part.

PubMed indexes the participants as middle-aged adults, older adults and people over 80, both men and women.

The researchers performed an analysis of 578 metabolites from 1215 plasma samples from 428 subjects at randomization (day 0), day 3 and 7.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some subjects received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The researchers performed a post-hoc metabolomics study of the VITdAL-ICU randomized double-blind, placebo-controlled trial.

What Was Measured

PubMed files the paper under topics including Cholecalciferol, Critical Illness, Intensive Care Units, Lysophospholipids, Metabolomics, Plasmalogens and Sphingomyelins.

The authors tagged it with the keywords Acylcarnitine, Phosphatidylethanolamine and Vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 428 subjects.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2021 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.