Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia

What Was Tested

Researchers studied IGF-1 LR3 in this randomized controlled trial publication.

In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1.

In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status.

Who Took Part

The study group was 3, adults.

The age groups tagged for this paper are young children, children and adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Because people in this IGF-1 LR3 study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the IGF-1 LR3 group a baseline to be compared against.

Helminth infection status was assessed by microscopy (Kato-Katz) and PCR.

What Was Measured

In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1.

Here, the researchers assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults.

The subject headings attached to it are Albendazole, Anthelmintics, Case-Control Studies, Cluster Analysis, Helminthiasis, Indonesia and Insulin-Like Growth Factor Binding Protein 3.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of IGF-1 LR3 in 3, adults.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2020 (Scientific reports), a journal based in England.

More context: the IGF-1 LR3 compound page, all human trials.