[The effect of administration of dietary supplement with calcium and vitamins D3 and B6 on calcium homeostasis and falls incidence in patients with high fracture risk undergoing medical rehabilitation].

What Was Tested

This clinical trial looks at Copper (Supplement).

The aim of the study was to evaluate the effect of long-term intake of a complex dietary supplement with calcium and vitamins D3 and B6 on calcium homeostasis and the frequency of falls in patients with high fracture risk undergoing medical rehabilitation.

Why It Was Studied

Elimination of vitamin D and calcium deficiencies is of particular importance in older patients undergoing medical rehabilitation after a serious illness, surgery or injury and having a high risk of fractures.

The study enrolled 109 women and 10 men (mean age 65.5±7.9 years) with high fracture risk who were undergoing medical rehabilitation.

Who Took Part

According to the abstract, 109 women were involved.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

After baseline examination, 41 patients have been receiving antiresorptive therapy already comprised group 1, and patients who didn't receive osteoporotic therapy were randomized into groups 2 (n=39) and 3 (control, n=39).

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.

What Was Measured

All patients underwent assessment of bone mineral density (BMD), calculation of absolute 10-year fracture risk according to FRAX, assessment of food calcium intake, etermination of biochemical parameters of calcium-phosphorus metabolism and bone remodeling (total calcium, inorganic phosphorus, alkaline phosphatase activity - by colorimetric method in blood serum; immunoreactive parathyroid hormone (PTH) and osteocalcin - by electrochemiluminescence immunoassay in blood serum; β-isomer of C-terminal telopeptide of type I collagen (CTx) and 25(OH)D in blood plasma - by immunochemiluminescence analysis), cases of falls and fractures were fixed.

PubMed files the paper under topics including Accidental Falls, Bone Density, Calcium, Dietary, Cholecalciferol, Dietary Supplements, Fractures, Bone and Incidence.

Author keywords: calcium intake, fall risk, fracture risk, rehabilitation and vitamin D.

What This Means in Plain Language

The paper is a randomized study of Copper (Supplement) in 109 women.

The publication is from 2020 (Voprosy pitaniia), a journal based in Russia (Federation).

More context: the Copper (Supplement) compound page, all human trials.