The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial

What Was Tested

The paper reports a study of HMG (Human Menopausal Gonadotropin) in the context of endometriosis, published as a randomized controlled trial.

Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin (HMG) for endometrial preparation compared with routine AC-FET.

Why It Was Studied

The study was also registered in the Iranian Registry of Clinical Trials on March 20th, 2020.

( IRCT20090526001952N12 at www.irct.ir , registered retrospectively).

Who Took Part

PubMed indexes the participants as adults, women only.

This randomized controlled trial was carried out on infertile PCOS patients who underwent IVF/ICSI and FET cycles in Arash Women's Hospital affiliated to Tehran University of Medical Sciences between September 2018 and January 2020.

PCOS diagnosis was based on the Rotterdam criteria.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got HMG (Human Menopausal Gonadotropin) and who got the comparison, which limits bias.

Eligible patients were randomly allocated into two groups: stimulated cycle with letrozole plus (HMG) (intervention group) and routine artificial hormonal endometrial preparation (control group).

What Was Measured

The subject headings attached to it are Cryopreservation, Embryo Implantation, Embryo Transfer, Endometrium, Letrozole, Menotropins and Outcome Assessment, Health Care.

The authors tagged it with the keywords Artificial cycle, Endometrial preparation, Frozen-thawed embryo transfer and Ongoing pregnancy rate.

What This Means in Plain Language

The paper is a randomized study of HMG (Human Menopausal Gonadotropin) in people with endometriosis.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (Reproductive biology and endocrinology : RB&E), a journal based in England.

More context: the HMG (Human Menopausal Gonadotropin) compound page, Endometriosis research.