Vitamin D Treatment during Pregnancy and Maternal and Neonatal Cord Blood Metal Concentrations at Delivery: Results of a Randomized Controlled Trial in Bangladesh.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The researchers examined maternal and neonatal cord blood levels of lead, cadmium, manganese, and mercury after supplementation with vitamin D during pregnancy.

Who Took Part

The age groups tagged for this paper are infants, women only.

The Maternal Vitamin D for Infant Growth trial was a randomized, placebo-controlled, multi-arm study of maternal vitamin D supplementation during pregnancy in Dhaka, Bangladesh (NCT01924013).

Each group had 118-239 maternal blood specimens and 100-201 cord blood samples analyzed.

How the Study Was Run

The design is described as randomized and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Metals were measured using inductively coupled plasma mass spectrometry.

Unadjusted estimates from linear regression models were expressed as percentage differences.

Cord blood cadmium was analyzed as detectable or undetectable with log-binomial regression.

What Was Measured

Topics PubMed links to this paper include Bangladesh, Calcium, Cholecalciferol, Dietary Supplements, Environmental Pollutants, Fetal Blood and Lead.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Environmental health perspectives), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.