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Zinc Supplementation in Preterm Neonates with Jaundice: Is it Beneficial?
Plain-language guide to PMID 33357203 (2021): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 33357203
- Journal
- Endocrine, metabolic & immune disorders drug targets
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Elfarargy MS et al. (4 authors)
- DOI
- 10.2174/1871530321666201223110241
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Neonatal jaundice is a common neonatal disease that has adverse effects on neonates, especially preterm neonates, when indirect bilirubin level is adequately high to pass the blood-brain barrier, causing bilirubin encephalopathy or kernicterus.
Zn supplementation should be provided to preterm neonates with jaundice.
Who Took Part
PubMed tags the participants as both men and women.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
A prospective randomized clinical trial, with the identification number TCTR20200504007, was conducted at Tanta University Hospital from July 2016 to March 2018 on 200 preterm neonates with jaundice.
What Was Measured
Neonatal jaundice is a common neonatal disease that has adverse effects on neonates, especially preterm neonates, when indirect bilirubin level is adequately high to pass the blood-brain barrier, causing bilirubin encephalopathy or kernicterus.
PubMed files the paper under topics including Combined Modality Therapy, Dietary Supplements, Egypt, Hyperbilirubinemia, Neonatal, Infant, Premature, Infant, Premature, Diseases and Jaundice, Neonatal.
Author keywords: Neonate, kernicterus, phototherapy, red blood cells (RBCs) and zinc.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2021 (Endocrine, metabolic & immune disorders drug targets), a journal based in United Arab Emirates.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.