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Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2.

Plain-language guide to PMID 33368619 (2021): observational study of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
33368619
Journal
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Year
2021
Study type
Observational Study
Authors
Gonçalves TJM et al. (9 authors)
DOI
10.1002/ncp.10612

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

The researchers verify the prevalence of low zinc levels among critically ill patients infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS).

Who Took Part

PubMed indexes the participants as older adults and people over 80, both men and women.

This is an observational study composed of patients admitted to the ICU.

How the Study Was Run

Demographics, anthropometric data for calculating body mass index (BMI), and laboratory data were obtained at admission: blood count, ferritin, arterial blood gas, serum zinc levels, and C-reactive protein.

Also, arterial oxygen tension (PaO2 ) divided by fractional inspired oxygen (FiO2 ) was calculated by the first arterial blood gas after intubation.

A diagnosis of severe ARDS was determined if the PaO2 /FiO2 ratio was ≤100 mm Hg.

What Was Measured

The researchers verify the prevalence of low zinc levels among critically ill patients infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS).

Topics PubMed links to this paper include COVID-19, Critical Illness, Intensive Care Units, Nutritional Status, Prevalence, SARS-CoV-2 and Zinc.

The authors tagged it with the keywords SARS virus and respiratory distress syndrome.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2021 (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.