← Human Trials & Peer-Reviewed Studies
Bronchodilatory effects of B-type natriuretic peptide in acute asthma attacks: a randomized controlled clinical trial
Plain-language guide to PMID 33393645 (2020): double-blind randomized controlled trial study of BNP (Nesiritide).
Key Facts
- PMID
- 33393645
- Journal
- Advances in respiratory medicine
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Motamed H et al. (5 authors)
- DOI
- 10.5603/ARM.a2020.0178
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.
Thus, the aim of this study w as to evaluate the effect of BNP in the treatment of acute asthma attacks.
Why It Was Studied
B-type natriuretic peptide (BNP) regulates different physiological processes such as blood pressure, cardiac growth, and neural and skeletal development.
Who Took Part
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
In this randomized clinical trial, patients with acute asthma attacks were enrolled.
The patients were divided randomly into two groups.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind BNP (Nesiritide) study, the assignments were hidden from both participants and investigators until the end.
Patients in the interventional group received BNP via intravenous infusion.
The patients in the control group received nebulized salbutamol.
Afterwards, peak flow meter findings, hemodynamic parameters, and estimation of the clinical severity of asthma in both groups were checked every 30 minutes.
What Was Measured
PubMed files the paper under topics including Administration, Inhalation, Albuterol, Asthma, Bronchodilator Agents, Forced Expiratory Volume, Maximal Midexpiratory Flow Rate and Natriuretic Peptide, Brain.
Author keywords: B-type natriuretic peptide and emergency medicine.
What This Means in Plain Language
The paper is a randomized and double-blind study of BNP (Nesiritide).
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (Advances in respiratory medicine), a journal based in Switzerland.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.