Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The aim of this study was to determine the effects of supplementation with these micronutrients on thyroid function, oxidative stress, and hs-CRP levels in patients with hypothyroidism.

Why It Was Studied

Hypothyroidism can occur due to deficiencies in micronutrients such as zinc, magnesium, and vitamin A.

Neither of the groups changed their diet or physical activity.

Who Took Part

The study group was 86 patients.

PubMed indexes the participants as young adults, adults, middle-aged adults and older adults.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

What Was Measured

The subject headings attached to it are Biomarkers, C-Reactive Protein, Dietary Supplements, Hypothyroidism, Magnesium, Oxidative Stress and Vitamin A.

The authors tagged it with the keywords Hs-CRP, Thyroid function and Zinc.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 86 patients.

The publication is from 2021 (Biological trace element research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.