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Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
Plain-language guide to PMID 33481179 (2021): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 100 children.
Key Facts
- PMID
- 33481179
- Journal
- World journal of pediatrics : WJP
- Year
- 2021
- Study type
- Randomized Controlled Trial
- Authors
- Hassanein SMA et al. (3 authors)
- DOI
- 10.1007/s12519-020-00401-0
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Who Took Part
The abstract describes 100 children taking part.
PubMed indexes the participants as young children and children, both men and women.
A prospective, double-blinded randomized control trial was carried out involving 100 children aged 2-12 years with sCP (level III-V of the Gross Motor Functional Classification system) and chronic constipation.
They were followed up in the Pediatric neurology clinic, Children's hospital, Ain Shams University, May 2017- January 2019.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the children nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some children received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
The subject headings attached to it are Cerebral Palsy, Chronic Disease, Constipation and Magnesium.
The authors tagged it with the keywords Bristol stool consistency scale, Constipation scale, Gross Motor Functional Classification system, Magnesium sulfate, Painful bowel evacuation and Spasticity.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 100 children.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2021 (World journal of pediatrics : WJP), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.